The first thing you should know about traveling the wine route through Mendoza: It's no Napa. The breathtaking Andean mountain range notwithstanding, the scenery around Argentina's main winemaking province is blighted by industrial sprawl. So for a weekend outside Buenos Aires—and since Mendoza is just a 90-minute flight away, you can do it in a couple of days—we think the smartest choice is to plunk yourself down at the new Cavas Wine Lodge. Cecilia Díaz Chuit and Martín Rigal run this romantic little hideaway, 20 minutes from the airport and set within 35 acres of old vines. There are 14 bungalows built in adobe style—each has its own plunge pool—as well as a spa with treatments that revolve around wine therapies. (We've never seen so many things done with crushed Malbec grapes.) Chef Sebastián Flores, who worked under Francis Mallmann in Buenos Aires, also makes use of native abundance: He reinvents Incan dishes with ingredients like baby goat, maize, and pumpkin. $375; dinner, $60; 54-261/410-6927; cavaswinelodge.com.