CC Africa, the safari company with some of the most luxurious lodges on the continent, has added another stunner. The South African Madikwe Safari Lodge sits near the Botswana border on one of the country's largest game reserves. The 16 suites—all reds and coppers and gabled ceilings—are divided among three camps, each with its own library, lounge, and lantern-lit dining room (called a boma). You might as well be here alone, though: It's impossible to see any other suite from your own. Even the open-air decks, which feature plunge pools and outdoor showers, are so sequestered that clothing is optional. Outside the camp, some 8,000 animals representing 28 species—brought to these grassy plains thanks to a national conservation initiative—roam the Madikwe Game Reserve. The Big Five are here, but keep your eyes especially peeled for an endangered wild Cape hunting dog. With a huge head on a scrawny body, it resembles something a kindergartner might draw. Rate, $390; 888-882-3742; www.ccafrica.com.